A Statistical View of Architecture Design

Computer architectures are becoming more and more complicated to meet the continuouslyincreasing demand on performance, security and sustainability from applications. Many factorsexist in the design and engineering space of various components and policies in the architectures,and it is not intuitive how these factors interact with each other and how they make impactson the architecture behaviors. Seeking for the best architectures for specific applicationsand requirements automatically is even more challenging. Meanwhile, the architecture designneed to deal with more and more non-determinism from lower level technologies. Emergingtechnologies exhibit statistical properties inherently, such as the wearout phenomenon inNEMs, PCM, ReRAM, etc. Due to the manufacturing and processing variations, there alsoexists variability among different devices or within the same device (e.g. different cells onthe same memory chip). Hence, to better understand and control the architecture behaviors,we introduce the statistical perspective of architecture design: by specifying the architecturaldesign goals and the desired statistical properties, we guide the architecture design with thesestatistical properties and exploit a series of techniques to achieve these properties.In the first part of the thesis, we introduce Herniated Hash Tables. Our architectural designgoal is that the hash table implementation is highly scalable in both storage efficiency andperformance, while the desired statistical property is to achieve as good storage efficiencyand performance as with uniform distributions given non-uniform distributions across hashbuckets. Herniated Hash Tables exploit multi-level phase change memory (PCM) to in-placeexpand storage for each hash bucket to accommodate asymmetrically chained entries. Theorganization, coupled with an addressing and prefetching scheme, also improves performancesignificantly by creating more memory parallelism.In the second part of the thesis, we introduce Lemonade from Lemons, harnessing devicewearout to create limited-use security architectures. The architectural design goal is tocreate hardware security architectures that resist attacks by statistically enforcing an upperbound on hardware uses, and consequently attacks. The desired statistical property is that thesystem-level minimum and maximum uses can be guaranteed with high probabilities despite ofdevice-level variability. We introduce techniques for architecturally controlling these boundsand explore the cost in area, energy and latency of using these techniques to achieve systemlevelusage targets given device-level wearout distributions.In the third part of the thesis, we demonstrate Memory Cocktail Therapy: A General,Learning-Based Framework to Optimize Dynamic Tradeoffs in NVMs. Limited write enduranceand long latencies remain the primary challenges of building practical memory systems fromNVMs. Researchers have proposed a variety of architectural techniques to achieve differenttradeoffs between lifetime, performance and energy efficiency; however, no individual techniquecan satisfy requirements for all applications and different objectives. Our architecturaldesign goal is that NVM systems can achieve optimal tradeoffs for specific applications andobjectives, and the statistical goal is that the selected NVM configuration is nearly optimal.Memory Cocktail Therapy uses machine learning techniques to model the architecture behaviorsin terms of all the configurable parameters based on a small number of sample configurations.Then, it selects the optimal configuration according to user-defined objectives whichleads to the desired tradeoff between performance, lifetime and energy efficiency

Complex I deficiency in m.3243A>G fibroblasts is alleviated by reducing NADH accumulation

Introduction: Mitochondrial disease is a spectrum of debilitating disorders caused by mutations in the mitochondrial DNA (mtDNA) or nuclear DNA that compromises the respiratory chain. Mitochondrial 3243A>G (m.3243 A>G) is the most common mutation showing great heterogeneity in phenotype. Previous studies have indicated that NADH: ubiquinone oxidoreductase (complex I) deficiency accompanied by a decreased nicotinamide adenine dinucleotide (NAD+)/reduced NAD+ (NADH) ratio may play a pivotal role in the pathogenesis of m.3243A>G mutation.Methods: To evaluate the potential effects of strategies targeting the imbalanced NAD+/NADH ratio in m.3243A>G mutation, we treated fibroblasts derived from patients with the m.3243 A>G mutation using nicotinamide riboside (NR) or mitochondria-targeted H2O-forming NADH oxidase (mitoLbNOX).Results: M.3243 A>G fibroblasts showed a significant reduction in complex I core subunit 6, complex I enzymatic activity, complex I-dependent oxygen consumption rate (OCR), and adenosine triphosphate (ATP) production compared to the controls. The NAD+/NADH ratio was also significantly reduced in m.3243 A>G fibroblasts, and, using fluorescence lifetime imaging microscopy, we also found that the NADH level was elevated in m.3243 A>G fibroblasts. After NR treatment, the NAD+/NADH ratio, complex I-dependent OCR, and ATP levels increased, whereas NADH levels remained unchanged. More excitingly, after treatment with mitoLbNOX, the NAD+/NADH ratio, complex I-independent OCR, and ATP levels increased more pronouncedly compared with the NR treatment group, accompanied by significantly reduced NADH levels.Discussion: The present study suggests that compared with repletion of NAD+ alone, the combination of this therapeutic modality with alleviation of NADH overload may amplify the treatment effect of restoring NAD+/NADH balance in m.3243A>G fibroblasts

Iron-Modified Biochar Strengthens Simazine Adsorption and Decreases Simazine Decomposition in the Soil

Currently, modified biochar has been successfully used in the remediation of soil polluted with heavy metals. However, the effects of the modified biochar on pesticides (such as simazine) are still unclear. Herein, the environmental fate of simazine, such as decomposition, leaching, and adsorption in unamended soil, in the soil amended with unmodified and modified biochar (biochar + FeCl(3), biochar + FeOS, biochar + Fe) were evaluated. In addition, an incubation experiment was also performed to observe the influence of modified biochar on the microbial community and diversity in the soil. The results showed that modified biochar significantly decreased the decomposition of simazine in the soil compared to its counterpart. Modified biochar also reduced the concentration of simazine in the leachate. Compared with the control, soil microbial biomass in the soil amended with unmodified biochar, biochar + FeCl(3), biochar + Fe, and biochar + FeOS was decreased by 5.3%, 18.8%, 8.7%, and 18.1%, respectively. Furthermore, modified biochar changed the structure of the microbial community. This shows that modified biochar could increase the soil adsorption capacity for simazine and change the amount and microbial community that regulates the fate of simazine in the soil. This study concludes that iron-modified biochar has positive and negative effects on the soil. Therefore, its advantages and side effects should be considered before applying it to the soil

Shared Microexponents: A Little Shifting Goes a Long Way

This paper introduces Block Data Representations (BDR), a framework for exploring and evaluating a wide spectrum of narrow-precision formats for deep learning. It enables comparison of popular quantization standards, and through BDR, new formats based on shared microexponents (MX) are identified, which outperform other state-of-the-art quantization approaches, including narrow-precision floating-point and block floating-point. MX utilizes multiple levels of quantization scaling with ultra-fine scaling factors based on shared microexponents in the hardware. The effectiveness of MX is demonstrated on real-world models including large-scale generative pretraining and inferencing, and production-scale recommendation systems

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Exploration and analysis of rural primary school teacher’s language violence

As the problem of rural education becomes more and more obvious while the supervision on stay-at-home children’s education becomes more and more difficult, rural primary school teacher’s language violence has become a new big problem today. This paper collected and investigated the improper language used by rural primary school teachers so as to analyze the features, harm, causes and solutions of language violence, trying to explore and analyze rural primary school teacher’s language violence from perspective of sociology and remind primary school teachers of rethinking. In subjective aspect, this paper hopes to improve rural primary school teacher’s comprehensive quality, establish specification for teacher’s language, lower rural teacher’s vocational burnout and alleviate the psychological pressure that exam-oriented education and rural stay-at-home children impose on teachers. In objective aspect, this paper hopes to enhance the supervision from society and administrative departments for education. All the above measures can be taken to effectively eliminate teacher’s language violence and resolve the crisis